Boran Altincicek, Ph.D.

P1020693

Background

Dr. rer. nat. habil. Boran Altincicek has been graduated from the University of Gießen in Germany. During preparing his Ph.D. thesis in Biology, he and his colleagues co-founded a biotech research spin-off company (Jomaa Pharmaka GmbH). Multidisciplinary research in host-pathogen-interactions and immunology, writing of patents and scientific publications were part of his work. After two years as Post-doc at the Institute of Biochemistry in Gießen, he took the opportunity to lead a research group and to investigate molecular adaptation of diverse insects to pathogens and the phenotypic plasticity and evolution of the insect immunity at the Institute of Phytopathology and Applied Zoology. Self-dependent teaching, own third-party funding, and numerous publications in international scientific journals resulted in his German “Habilitation” in the year 2009. Then, funded by the German Research Foundation-DFG with the Heisenberg fellowship in Zoology, he got the opportunity to work on insect ecology and evolution as a Visiting Scientist and Lecturer with Professor Nicole Gerardo at the Emory University in Atlanta, GA, USA. Prior to his current working as freelancer and consultant in Lilongwe, Malawi (Africa) he was “Privatdozent” (equivalent to Assoc. Professor) in Zoology and Ecology at the Agricultural Faculty of the University of Bonn, Germany.

Details of publications and citations:

Education

  • PhD (Biology) with distinction, University of Gießen – 2002
  • MSc (Biology) University of of Gießen -1997
  • BSc (Biology) University of of Gießen -1994

Professional experience

  • 2012 – present: Consultant/Freelancer for scientific writing, project development, biodiversity and statistics, Lilongwe, Malawi
  • 2010 – 2012: Associate Professor for Agricultural Zoology and Ecology, University of Bonn, Germany
  • 2009 – 2010: Visiting Scientist/Lecturer for Zoology, Evolution and Ecology, Emory University, Atlanta, USA
  • 2005 – 2009: Assistant Professor for Applied Zoology, University of Gießen, Germany
  • 2002 – 2005: Post-doc in Molecular Biology and Biochemistry, University of Gießen, Germany

Research:

wordcloud1Wordcloud of my research made with R!

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Bibliometrics

ResearcherID: C-1191-2009. I have (co-)authored 2 books, 1 review article, 4 patents and 44 primary research publications in international, peer-reviewed journals (first author, n=26; corresponding author, n=12).
ISI (Web of Science) citation report of primary research articles:

Publications listed: 43

Times cited: 2440

h-index: 23

i10-index: 34

 

Research publications in international journals with the peer-review process

2013

44. B. ter Braak, A.M. Laughton, B. Altincicek, B.J. Parker, N. M. Gerardo. 2013. Exposure to Bacterial Signals Does Not Alter Pea Aphids’ Survival upon a Second Challenge or In-vestment in Production of Winged Offspring. PLOS ONE 8: e73600. (IF 4.092)

43. Altincicek B., A. Elashry, N. Guz, F.M.W. Grundler, A. Vilcinskas, H.-W. Dehne. 2013. Next generation sequencing based transcriptome analysis of septic-injury responsive genes in the beetle Tribolium castaneum. PLOS ONE 8: e52004. (IF 4.092)

42. Parker B. J., C. J. Spragg, B. Altincicek, N. M. Gerardo. 2013. Symbiont-mediated pro-tection against fungal pathogens in pea aphids: a role for pathogen specificity? Appl Envi-ron Microbiol.  79, 2455-8. (IF 3.829)

2012

41. Altincicek B.*, J. L. Kovacs*, N. M. Gerardo. 2012. Horizontally-transferred fungal carotenoid genes in the two-spotted spider mite Tetranychus urticae. Biol Letters. 8: 253-7. (IF 3.651)

2011

40. Altincicek B*, Vogel H*, Glockner G, Vilcinskas A. 2011. A comprehensive transcriptome and immune-gene repertoire of the lepidopteran model host Galleria mellonella. BMC Genomics. 12: 308. (IF 4.206)

39. Altincicek, B., B. ter Braak, A. M. Laughton, K. I. Udekwu, N. M. Gerardo. 2011. Escherichia coliK-12 pathogenicity in the pea aphid, Acyrthosiphon pisum, reveals reduced antibacterial defense in aphids. Dev Comp Immunol. 35: 1091-7. (IF 3.293)

38. Laughton, A.M., J.R. Garcia, B. Altincicek, M.R. Strand, N.M. Gerardo. 2011. Characterisation of immune responses in the pea aphid, Acyrthosiphon pisum. J Insect Physiol. 57: 830-9. (IF 2.310)

2010

37. Altincicek, B., M. Fischer, M. Fischer, et al. 2010. Role of matrix metalloproteinase ZMP-2 in pathogen resistance and development in Caenorhabditis elegans. Dev Comp Immunol. 34:1160-9. (IF 3.293)

36. The International Aphid Genomics Consortium (including B. Altincicek). 2010. Genome Sequence of the Pea Aphid Acyrthosiphon pisum. PLoS Biol. 8:e1000313. (IF 12.469)

35. Gerardo, N. M., B. Altincicek, C. Anselme et al. 2010. Immunity and other defenses in pea aphids, Acyrthosiphon pisum. Genome Biol. 11:R21 (IF 6.885)

34. Mukherjee, K., B. Altincicek, T. Hain, et al.2010. Galleria mellonella as model system to study Listeria pathogenesis. Appl Environ Microbiol. 76:310-7. (IF 3.778)

2009

33. Altincicek, B., A. Berisha, K. Mukherjee, et al. 2009. Identification of collagen IV derived danger/alarm signals in insect immunity by nanoLC-FTICR MS. Biol Chem. 390:1303-11. (IF 3.603)

32. Altincicek, B. and A. Vilcinskas.2009. Septic injury inducible genes in medicinal maggots of the green blow fly Lucilia sericata. Insect Mol Biol. 18:119-25. (IF 2.669)

31. Knorr, E., H. Schmidtberg, A. Vilcinskas, and B. Altincicek. 2009. MMPs regulate both development and immunity in the Tribolium model insect. PLoS ONE. 4(3):e4751. (IF 4.411)

30. Rahnamaeian, M., G. Langen, J. Imani, W. Khalifa, B. Altincicek, D. von Wettstein, K.H. Kogel, and A. Vilcinskas. 2009. Insect peptide metchnikowin confers on barley a selective capacity for resistance to fungal ascomycetes pathogens. J Exp Bot. 60: 4105-14. (IF 4.818)

2008

29. Altincicek, B., J. Gross, and A. Vilcinskas.2008. Wounding-mediated gene expression and accelerated viviparous reproduction of the pea aphid Acyrthosiphon pisum. Insect Mol Biol. 17:711-6. (IF 2.669)

28. Altincicek, B., E. Knorr, and A. Vilcinskas.2008. Beetle immunity: Identification of immune-inducible genes from the model insect Tribolium castaneum. Dev Comp Immunol. 32:585-95. (IF 3.293)

27. Altincicek, B., S. Stoetzel, M. Wygrecka, et al. 2008. Host-derived extracellular nucleic acids enhance innate immune responses, induce coagulation, and prolong survival upon infection in insects. J Immunol. 181:2705-12. (IF 5.745)

26. Altincicek, B. and A. Vilcinskas.2008. Comparative analysis of septic injury-inducible genes in phylogenetically distant model organsims of regeneration and stem cell research, the planarian Schmidtea mediterranea and the cnidarian Hydra vulgaris. Front Zool. 5:6. (IF 2.519)

25. Altincicek, B. and A. Vilcinskas.2008. Identification of a lepidopteran matrix metalloproteinase with dual roles in metamorphosis and innate immunity. Dev Comp Immunol. 32:400-9. (IF 3.293)

24. Altincicek, B. and A. Vilcinskas. 2008. Identification of immune inducible genes from the velvet worm Epiperipatus biolleyi(Onychophora). Dev Comp Immunol. 32:1416-21. (IF 3.293)

23. Tribolium Genome Sequencing Consortium (including B. Altincicek).2008. The first genome sequence of a beetle, Tribolium castaneum, a model for insect development and pest biology. Nature. 452:949-55. (IF 36.101)

2007

22. Altincicek, B., M. Linder, D. Linder, et al.2007. Microbial metalloproteinases mediate sensing of invading pathogens and activate innate immune responses in the lepidopteran model host Galleria mellonella. Infect Immun. 75:175-83. (IF 4.098)

21. Altincicek, B. and A. Vilcinskas.2007. Analysis of the immune-related transcriptome of a lophotrochozoan model, the marine annelid Platynereis dumerilii. Front Zool. 4:18. (IF 2.519)

20. Altincicek, B. and A. Vilcinskas.2007. Analysis of the immune-inducible transcriptome from microbial stress resistant, rat-tailed maggots of the drone fly Eristalis tenax. BMC Genomics. 8:326. (IF 4.206)

19. Altincicek, B. and A. Vilcinskas.2007. Identification of immune-related genes from an apterygote insect, the firebrat Thermobia domestica. Insect Biochem Mol Biol. 37:726-31. (IF 4.018)

18. Wedde, M., C. Weise, R. Nuck, B. Altincicek, and A. Vilcinskas.2007. The insect metalloproteinase inhibitor gene of the lepidopteran Galleria mellonellaencodes two distinct inhibitors. Biol Chem. 388:119-27. (IF 3.603)

2006

17. Altincicek, B., A. Shibamiya, H. Trusheim, et al. 2006. A positively charged cluster in the epidermal growth factor-like domain of Factor VII-activating protease (FSAP) is essential for polyanion binding. Biochem J. 394:687-92. (IF 5.016)

16. Altincicek, B. and A. Vilcinskas.2006. Metamorphosis and collagen-IV-fragments stimulate innate immune response in the greater wax moth, Galleria mellonella. Dev Comp Immunol. 30:1108-18. (IF 3.293)

15. Langen, G., J. Imani, B. Altincicek, et al.2006. Transgenic expression of gallerimycin, a novel antifungal insect defensin from the greater wax moth Galleria mellonella, confers enhanced resistance to phytopathogenic fungi in tobacco. Biol Chem. 387:549-57. (IF 3.603)

1999 – 2002

14. Altincicek, B., E.C. Duin, A. Reichenberg, R. Hedderich, A.K. Kollas, M. Hintz, S. Wagner, J. Wiesner, E. Beck and H. Jomaa.2002. LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis. FEBS Lett. 532:437-40. (IF 3.601)

13. Altincicek, B., A.K. Kollas, M. Eberl, S. Sanderbrand, U. Bahr, A. Reichenberg, E. Beck, F. Donald, J. Wiesner, M. Hintz, and H. Jomaa.2002. Accumulation of a potent gdT cell stimulator after deletion of the lytB gene in Escherichia coli. Immunology 106:200-11. (IF 3.302)

12. Kollas, A.K., E.C. Duin, M. Eberl, B. Altincicek, M. Hintz, A. Reichenberg, D. Henschker, A. Henne, I. Steinbrecher, D.N. Ostrovsky, R. Hedderich, E. Beck, H. Jomaa and J. Wiesner. 2002. Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis. FEBS Lett. 532:432-6. (IF 3.601)

11. Altincicek, B., A.K. Kollas, M. Eberl, J. Wiesner, S. Sanderbrand, M. Hintz, E. Beck, and H. Jomaa. 2001. LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. FEBS Lett. 499:37-40. (IF 3.601)

10. Altincicek, B., A.K. Kollas, S. Sanderbrand, J. Wiesner, M. Hintz, E. Beck, and H. Jomaa. 2001. GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. J Bacteriol. 183:2411-6. (IF 3.726)

9. Altincicek, B., J. Moll, N. Campos, G. Foerster, E. Beck, J.F. Hoeffler, C. Grosdemange-Billiard, M. Rodriguez-Concepcion, M. Rohmer, A. Boronat, M. Eberl, and H. Jomaa. 2001. Cutting edge: human gdT cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. J Immunol. 166:3655-8. (IF 5.745)

8. Hintz, M., A. Reichenberg, B. Altincicek, U. Bahr, R. M. Gschwind, A.K. Kollas, E. Beck, J. Wiesner, M. Eberl, and H. Jomaa.2001. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gdï€ T cells in Escherichia coli. FEBS Lett. 509:317-22. (IF 3.601)

7. Reichenberg, A., J. Wiesner, C. Weidemeyer, E. Dreiseidler, S. Sanderbrand, B. Altincicek, E. Beck, M. Schlitzer, and H. Jomaa.2001. Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity. Bioorg Med Chem Lett. 11:833-5. (IF 2.661)

6. Wiesner, J., S. Sanderbrand, B. Altincicek, E. Beck, and H. Jomaa.2001. Seeking new targets for antiparasitic agents. Trends Parasitol. 17:7-8. (IF 4.906)

5. Altincicek, B., M. Hintz, S. Sanderbrand, J. Wiesner, E. Beck, and H. Jomaa. 2000. Tools for discovery of inhibitors of the 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase: an approach with enzymes from the pathogenic bacterium Pseudomonas aeruginosa. FEMS Microbiol Lett. 190:329-33. (IF 2.040)

4. Altincicek, B., S.P. Tenbaum, U. Dressel, D. Thormeyer, R. Renkawitz, and A. Baniahmad. 2000. Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita. J Biol Chem. 275:7662-7. (IF 5.328)

3. Wiesner, J., M. Hintz, B. Altincicek, S. Sanderbrand, C. Weidemeyer, E. Beck, and H. Jomaa. 2000. Plasmodium falciparum: detection of the deoxyxylulose 5-phosphate reductoisomerase activity. Exp Parasitol. 96:182-6. (IF 1.869)

2. Dressel, U., D. Thormeyer, B. Altincicek, A. Paululat, M. Eggert, S. Schneider, S. P. Tenbaum, R. Renkawitz, and A. Baniahmad.1999. Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. Mol Cell Biol. 19:3383-94. (IF 6.188)

1. Jomaa, H., J. Wiesner, S. Sanderbrand, B. Altincicek, C. Weidemeyer, M. Hintz, I. Turbachova, M. Eberl, J. Zeidler, H. K. Lichtenthaler, D. Soldati, and E. Beck. 1999. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science. 285:1573-6. (IF 31.364)

Invited review article

1. B. Altincicek. The innate immunity in the cnidarian Hydra vulgaris. 2009. Invertebrate Survival Journal. 6:106-113.

Monograph

1. B. Altincicek: Zoologie und die Evolution vom Einzeller zum Menschen. (ISBN:978-1311588104)

2. B. Altincicek: Step by step practical guide with Statistics (from ANOVA to survival analysis) in Biological Sciences: Or: Help, how can I analyze my“damned” scientific data correctly and in an easy way with free R! (ISBN: 978-1301217069)

3. B. Altincicek: Identifizierung neuer Enzyme des Mevalonat-unabhaengigen Methylerythritol-4-phosphat Stoffwechselweges zur Isoprenoidbiosynthese (ISBN: 978-3835953017)

Patents

1. WO2004035810; DE10247478: Determining activity of enzymes in non-mevalonate isoprenoid pathway, for screening for microbicides and herbicides, involves incubation with a substrate and electron-transfer agent.

2. WO2004019956; DE10237085: Treatment or prevention of parasitic helminth infections, especially filariasis, in humans or animals, using oxyamino-substituted phosphonic or phosphinic acid compounds.

3. WO2003009855; EP1408984; US020060030546, US020080249067, DE10135395; DE10134705: New acyclic or cyclic organophosphorus compounds, are gamma-delta-T cell activators useful e.g. as medicaments for treating asthma, chronic bronchitis, ulcerative colitis, autoimmune diseases or allergies.

4. WO200295011; EP1381686; US020080206267, DE10119905: Enriching intermediates in the mevalonate-independent pathway of isoprenoid synthesis, useful for therapeutic activation of T cells, comprises altering enzymatic activity in the pathway.

Theses

1. Boran Altincicek (2008) Kumulative Habilitationsschrift: Comparative Immunology of Invertebrates : Molecular mechanisms and novel antimicrobial peptides. Download PDF (2.6 MB)

2. Boran Altincicek (2002) Inaugural-Dissertation: Identifizierung neuer Enzyme des Mevalonat-unabhaengigen Methylerythritol-4-phosphat Stoffwechselweges zur Isoprenoidbiosynthese. Download PDF (5.29 MB)

3. Boran Altincicek (1997) Diplomarbeit: Charakterisierung der Interaktion des Retinoblastoma-Tumorsuppressors und des Thyroidhormonrezeptors mit Alien, einem neuartigen Co-Repressor. Download PDF (2.62 MB)

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